📚 Research Digest

Wednesday, February 25, 2026

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Have you tried switching it off and on again? Mechanisms and therapeutic prospects of resetting homeostatic set points in medicine and neuropsychiatry Theoretical 👍 👎
Thomas Pollak, Michael Levin, Anjali Bhat et al. (6 authors) • PsyArXiv
Finding: The paper proposes that chronic neuropsychiatric disorders involve maladaptive homeostatic set points that can be therapeutically "reset" through interventions that create temporary high-plasticity states, requiring careful scaffolding to guide systems toward healthier equilibria.

Why it matters: The framework of disrupting entrenched patterns to enable recalibration could inform approaches to overcoming cognitive biases, facilitating behavioral change, and understanding how interventions can reset maladaptive team or individual patterns.

Jargon: Active inference - a theoretical framework where organisms minimize prediction errors; homeostatic set points - the target values biological systems maintain through regulatory mechanisms.
No methodology concerns noted.
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